Postdoc translational tumor immunology in multiple myeloma

With the advent of novel immunotherapies such as conventional antibodies, T cell–targeting antibodies, antibody–drug conjugates and CAR T cells, the treatment of multiple myeloma is advancing rapidly, opening new possibilities for a potential cure.

Over the past decade our multiple Myeloma team has made significant contributions to the development and improvement of immunotherapy of multiple myeloma, as well as to understanding immune aging processes, through comprehensive functional, phenotypic, and genetic analyses of large, dedicated patient biobanks.

To elevate our research to the next level, we are seeking a highly motivated postdoctoral researcher to investigate how immune aging and the components of the tumor microenvironment (TME) influence treatment responses in multiple myeloma.

You will apply and further develop cutting-edge immune profiling technologies to uncover immune mechanisms underlying therapeutic efficacy and resistance.

• You will perform multiparameter immune phenotyping of bone marrow aspirates and peripheral blood samples to deepen our insights into how immune dysfunction negatively affects immunotherapy outcomes in multiple myeloma. You will focus on novel T cell immunotherapies such as CAR T cell therapy and T cell redirecting bispecific and trispecific antibodies. A better understanding of resistance mechanisms may lead to novel strategies to improve efficacy of immunotherapy.
• You will set up and execute advanced techniques including spectral flow cytometry, imaging mass - cytometry (IMC/Image CyTOF) and spatial genomics on bone marrow samples to deepen our understanding of TME and therapy outcomes.
• You will conduct functional immunological assays to deepen our insights into immune exhaustion and senescence, and evaluate novel strategies to enhance efficacy of immunotherapy by mitigating immune dysfunction or immunosuppressive components in TME.
• You will collaborate with a multidisciplinary team of immunologists, hematologists, and bioinformaticians.
• You will present findings at internal and external scientific meetings.

• You hold a PhD in immunology, tumor biology, or a related field.
• You have strong expertise in tumor immunology.
• You have demonstrated affinity for advanced immune profiling techniques  and  functional immune assays.
• Experience with high-dimensional data analysis is a plus.
• You have excellent communication and collaborative skills. You are fluent in English, both written and spoken.