Postdoc Metastatic Melanoma on Chip

As the most aggressive form of skin cancer, melanoma is characterized by early immune suppression and metastasis. Systemic immune checkpoint blockade (ICB) is effective for (over) half of the patients, but can cause at times severe autoimmunity. In order to further develop and test novel therapeutics aimed at immune potentiation of melanoma-conditioned tumor draining lymph nodes, specialized testing platforms are required.

This project aims to develop a metastatic melanoma-on-chip (MMoC), combining our reconstructed human melanoma-in-skin model with draining lymphatics and a reconstructed lymph node, including the relevant immune subsets, to recapitulate early immune suppressive events followed by testing of an immune modulator.

As a Post-Doc you will:

• Setup methods to establish the Metastatic Melanoma on Chip model;
• Assess functionality of the MMoC platform;
• Perform immune phenotyping of the model, and test immune modulators;
• Design and write scientific articles and present data on scientific conferences.

We are looking for a highly motivated teamplayer with:

• A recent PhD degree with experience in one or more of the following fields: biomedical sciences, tissue engineering, (tumor)-immunology or related fields. We are particularly looking for a starting post-doc;
• Experience with in vitro culture models, flowcytometry, tissue engineering and/or microfluidics is a pre;
• Team player with strong collaborative skills and proactive attitude;
• Excellent written and oral communication skills in English.