Postdoc Cerebrale microcirculatie bij beroerte

For several years now, patients suffering from acute ischemic stroke have been treated with mechanical thrombectomy, where the blood clot is removed using a catheter. However, even after successful removal of the clot, blood flow to the brain often does not fully recover. Such incomplete reperfusion can lead to further infarct growth and contributes to the still poor outcomes in stroke patients.

In this project, we will investigate the vasculature during stroke and after thrombectomy to unravel the mechanisms involved in this incomplete reperfusion. We will also test new therapeutic interventions. To achieve this, we make use of animal models, cell cultures, and advanced microscopic imaging. The results of this project will help us to better understand the cerebral vasculature during stroke and recanalization therapy, and to identify potential new therapeutic strategies to improve treatment efficacy and patient outcomes.

A PhD student will also be appointed for this project. 

You will investigate neurovascular processes and test new interventions aimed at reducing brain tissue damage after stroke. Using advanced in vivo microscopy and in vitro models, your work will include:

• Designing and conducting in vivo and in vitro stroke experiments;
• Improving microscopy protocols and solving technical & practical challenges;
• Analyzing large imaging datasets to understand microvascular behavior during and after stroke;
• Initiating grant applications to secure additional funding;
• Collaborating closely within an interdisciplinary research team.

You hold a PhD in neuroscience, cardiovascular sciences, or imaging.

In addition, you bring:

• Experience with animal research (including Article 9 certification or equivalent);
• Hands-on experience with in vivo models (such as MCAO) and in vitro systems (such as iPSC cultures, vessel-on-a-chip, or brain organoids);
• Proficiency in standard laboratory techniques, including qPCR, Western blot, ELISA, IHC, and confocal microscopy;
• Affinity with or experience in programming (Matlab/Python);
• Excellent command of English, both written and spoken.