PhD spatial proteomics

Frontotemporal dementia (FTD) encompasses a group of neurodegenerative diseases that progressively affect behavior, movement, personality and/or language. We aim to identify the molecular and cellular causes of FTD that trigger its onset and early progression with the aim to design evidence-based treatment.

We are looking for a highly motivated researcher to join our team. You will design and execute proteomics studies on human brain tissue of sporadic patients and human iPSC-derived neurons. The aim is to understand the molecular and cellular dysfunctions that lead to cell-type-specific vulnerability that may be causative to FTD through highly innovative single-cell and spatial (prote)-omics technologies.

Would you like to know more about the different phases within the PhD trajectory? You can read more about this on this page.

As a member of our team, you will:

• design and execute proteomics studies to identify cell-type specific vulnerability;
• perform experiments in human postmortem FTD brain tissue and patient iPSC-derived neuronal cell cultures;
• aid in data analysis and integration of -omics datasets to characterize cell-specific functional dysregulation and cellular crosstalk;
• contribute to scientific reporting, publications, and regulatory-ready data packages;
• supervise undergraduate students;
• report on your findings in regular work meetings, conferences, and scientific publications in reputable journals.

This position offers a unique opportunity to contribute to translational neuroscience in a dynamic team of proteomic and neuroscience researchers in the search for fundamental insights with real-world therapeutic impact. You have:

• a master's degree in neuroscience, biomolecular science, or biochemistry;
• proven expertise and skills with molecular and cellular work as part of an internship;
• experience with programming and data analysis (Python, R). Expertise with omics datasets is a strong advantage;
• strong written and verbal communication skills in English.

We are looking for the following personality traits:

• excellent organisational and management skills;
• working diligently and with high accuracy;
• a team player who enjoys collaborating in an interdisciplinary environment;
• a creative and independent thinker who takes initiative.