Influenza viruses infect ~700,000,000, and kill ~650,000, people worldwide each year. Much of this disease burden derives from the evolution of influenza viruses to escape immunity induced by prior infections and vaccinations. Simultaneously, our immune responses evolve with each infection to attack the new virus variants. The result is a continuous evolutionary arms race between virus and host. In this project, you will develop a new protein microarray for characterizing serological antibody responses to seasonal influenza viruses to study the accumulation and waning of immunity based on longitudinally collected serum samples from hundreds of people for >30 years. You will lead the work on protein expression for constructing the microarray. This is a new project that has the potential to reshape the understanding of accumulation of respiratory virus immunity, influence future vaccine design, and lead to substantial follow-on funding.
This research project is funded by a 5 year NWO/ZonMw Vici grant to Prof dr Colin Russell focused on characterizing how our antibody-mediated immune response changes upon infection/re-infection and how these changes drive virus evolution. The portion of the project related to the role advertised here will be pursued in collaboration with Prof dr Rogier Sanders, Dr Marit van Gils, and Dr Dirk Eggink. You will be based in an active research group of ~20 people with a wide range of wet lab and computational expertise at Amsterdam UMC, location AMC in the Department of Medical Microbiology.
We are looking for a highly motivated and enthusiastic Postdoctoral Researcher (Postdoc) with experience in protein structural biology and protein expression.
You have a PhD and track record of publishing your results in peer reviewed journals.
You have outstanding experimental research skills and academic skills, are well organized, goal-oriented and results-driven, and have a strong team spirit, but you can also function independently.
You have excellent communication skills and are fluent in speaking and writing in English.
To apply, please submit: 1. a full academic CV including peer reviewed publications, presentations at conferences, and other relevant experience; 2. a letter describing your motivation in applying for the position and suitability for the role along with the names, job titles, and email addresses of three references.
The first round of job interviews will take place at the end of October 2021.
Do you have any questions about this positions? Please contact Prof dr Colin Russell, email@example.com
For more information about the application procedure, please contact Tanja Hart, Recruitment Adviser, via T: 06-21603178 or E: firstname.lastname@example.org
A reference check can be part of the procedure.