The research groups of Prof. Dr. Stan van de Graaf and Dr. Piter Bosma have vacancies for a 3-year postdoc position. The successful candidate will start to develop an independent research program focused on one or both of two research areas detailed below with outlook on a permanent staff position in the Tytgat Institute for Liver and Intestinal Research.
This department houses ~70 basic/translational scientists, is connected to the clinical departments (Gastroentrology & Hepatology, Surgery, etc) and embedded in the Amsterdam Gastroenterology Endocrinology Metabolism research institute
Thematic area 1: Metabolite dynamics and liver-centered organ crosstalk. A plethora of signals comes from the intestine in the form of metabolites produced by the microbiome with food as the source. Different types of food or food components are associated with improved health or with disease. Similarly, dysbiosis, or an aberrant intestinal microbiota composition and function, associates with many diseases. The liver is the first organ to detect and integrate the signals from gut-derived metabolites and plays a dominant role in controlling their spatial and temporal signalling. The ultimate goal of this research project is to exploit intestinal-derived signals by modulating hepatic metabolite uptake and/or catabolism to prevent or target common metabolic diseases, such as type 2 diabetes, NAFLD and atherosclerosis.
Thematic area 2: The overall aim of this research area is the development of novel treatment strategies for inherited liver disorders. Historically, the department is very strong in development of viral vector based gene therapy. We will be moving towards gene repair and gene editing using lipid nanoparticle (LNP) vectors to deliver Cas RNA or protein guide RNAs. Furthermore, we will explore translation of technological advancements in (temporal) gene-modification also to other applications beyond rare inherited disorders.
We are looking for a highly driven, motivated and enthusiastic researcher with:
Van de Graaf and Bosma run independent research groups that are part of the Tytgat Institute for Liver and Intestinal Research, the laboratory where the basic and pre-clinical research of the Department of Gastroenterology & Hepatology of the Amsterdam University Medical Centre (Amsterdam UMC) is concentrated.
The Tytgat Institute houses more than 70 basic/clinical scientists, and is one of the leading international research centers in gastroenterology and hepatology.
The first round with interviews are planned beginning of October. For foreign candidates this can be arranged via Teams/Zoom and are mainly exploratory, so see whether there is a match in skills & interest with the lab/position. The subsequent second round will involve a presentation on site, which will also allow you to see the lab, meet the groupmembers and have more time to check for a possible match.
During the publication period, applications will be handled continuously. If the vacancy is filled, it will be closed prematurely.
For more information about the vacancy please contact Stan van de Graaf via firstname.lastname@example.org.
For more information about the application process please contact Tanja Hart, Recruitment adviser, via email@example.com or via 06-21603178.
A reference check, screening and hiring test may be part of the procedure. Read hier whether this also applies to you.
If you join us, we ask for a VOG (Certificate of Good Conduct)