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Postdoc/Junior Group Leader Liver Research

Are you striving for a career in academic liver research with a focus on metabolic and/or cholestatic diseases? The Tytgat Institute for Liver and Intestinal Research is looking for a postdoctoral researcher with high potential to eventually complement our staff as group-leader.
Postdoc/Junior Group Leader Liver Research
Solliciteer direct
  • Aantal uur: 32 36 uur per week
  • Werklocatie: Locatie AMC
  • Contractvorm: bepaalde tijd met uitzicht op vast
  • Salaris: € 3.047 - € 4.800
  • Reageer tot en met: 9 oktober 2022
Solliciteer direct Reageer binnen 7 dag(en)
Wat ga je onderzoeken?

The research groups of Prof. Dr. Stan van de Graaf and Dr. Piter Bosma have vacancies for a 3-year postdoc position. The successful candidate will start to develop an independent research program focused on one or both of two research areas detailed below with outlook on a permanent staff position in the Tytgat Institute for Liver and Intestinal Research.

This department houses ~70 basic/translational scientists, is connected to the clinical departments (Gastroentrology & Hepatology, Surgery, etc) and embedded in the Amsterdam Gastroenterology Endocrinology Metabolism research institute

    Vragen over deze functie?
    Tanja Hart Tanja Hart +31621603178 Recruitment adviseur
    Wat ga je doen?

    Thematic area 1: Metabolite dynamics and liver-centered organ crosstalk. A plethora of signals comes from the intestine in the form of metabolites produced by the microbiome with food as the source. Different types of food or food components are associated with improved health or with disease. Similarly, dysbiosis, or an aberrant intestinal microbiota composition and function, associates with many diseases. The liver is the first organ to detect and integrate the signals from gut-derived metabolites and plays a dominant role in controlling their spatial and temporal signalling. The ultimate goal of this research project is to exploit intestinal-derived signals by modulating hepatic metabolite uptake and/or catabolism to prevent or target common metabolic diseases, such as type 2 diabetes, NAFLD and atherosclerosis.

    Thematic area 2: The overall aim of this research area is the development of novel treatment strategies for inherited liver disorders. Historically, the department is very strong in development of viral vector based gene therapy. We will be moving towards gene repair and gene editing using  lipid nanoparticle (LNP) vectors to deliver Cas RNA or protein guide RNAs. Furthermore, we will explore translation of technological advancements in (temporal) gene-modification also to other applications beyond rare inherited disorders.

    Wat neem je mee?

    We are looking for a highly driven, motivated and enthusiastic researcher with:

    • A PhD in a field related to biomedical molecular sciences.
    • Interest in innovative technologies and pushing the boundaries of research through technology-driven applications;
    • Experience with in vitro and in vivo models. Experience with advanced ex vivo models (precision cut liver slices, organoids, perfusion systems) is a strong advantage.
    • A flexible, pro-active team spirit but you can also work independently;
    • Excellent communications skills in English, both written and verbal.
    • A strong collaboration network.
    •  A strong publication record in prestigious international journals.
    Wat bieden we jou?
    • The unique opportunity to work in a multidisciplinary international translational research team.
    • Access to, and training in, state-of-the-art technologies in biomedical research.
    • A dynamic working environment in which quality, professionalism and team spirit are encouraged (with English as the main language).
    • Training in project management (e.g., supervision of students, budget management).
    • The position is for 3 years. We first offer a fixed term contract for 1 year, which under normal circumstances will be prolonged with 2 years. You are encouraged to develop your own independent group in the final part of this project and long-term career opportunities are present if successful.
    • In addition to a good basic salary, you will receive, among other things, 8.3% year-end bonus and 8% vacation allowance. Calculate your net salary here.
    • Pension accrual with Befrank, a modern, transparent and undeerstandable pension plan.
    • Reimbursement of 75% of your public transport costs. Would you rather travel by bike? Then we have a good bicycle scheme.

    Waar ga je werken?

    Van de Graaf and Bosma run independent research groups that are part of the Tytgat Institute for Liver and Intestinal Research, the laboratory where the basic and pre-clinical research of the Department of Gastroenterology & Hepatology of the Amsterdam University Medical Centre (Amsterdam UMC) is concentrated.

    The Tytgat Institute houses more than 70 basic/clinical scientists, and is one of the leading international research centers in gastroenterology and hepatology.

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    Laten we kennis maken

    The first round with interviews are planned beginning of October. For foreign candidates this can be arranged via Teams/Zoom and are mainly exploratory, so see whether there is a match in skills & interest with the lab/position. The subsequent second round will involve a presentation on site, which will also allow you to see the lab, meet the groupmembers and have more time to check for a possible match.

    During the publication period, applications will be handled continuously. If the vacancy is filled, it will be closed prematurely. 

    For more information about the vacancy please contact Stan van de Graaf via k.f.vandegraaf@amsterdamumc.nl.

    For more information about the application process please contact Tanja Hart, Recruitment adviser, via t.hart@amsterdamumc.nl or via 06-21603178.

    A reference check, screening and hiring test may be part of the procedure. Read hier whether this also applies to you.

    If you join us, we ask for a VOG (Certificate of Good Conduct)