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PhD Genetic & environmental contributors to Alzheimer’s blood-biomarker changes

Do you want to contribute to the implementation of Alzheimer's blood tests in clinical practice?
PhD Genetic & environmental contributors to Alzheimer’s blood-biomarker changes
Solliciteer direct
  • Aantal uur: 32 36 uur per week
  • Werklocatie: Locatie VUmc
  • Contractvorm: opleiding
  • Salaris: € 2.570 - € 3.271
  • Reageer tot en met: 22 mei 2022
Solliciteer direct Reageer binnen 4 dag(en)
Wat ga je onderzoeken?

Alzheimer’s Disease (AD) is the most common cause of dementia. Recent studies showed blood-based biomarkers to be promising for identifying core pathologies of AD, even in the predementia stage where individuals still show normal cognitive functioning. In order to develop treatment strategies for AD, we need to know which factors drive the first pathological signs. Twin and family studies can be powerfull in identifying genetic and environmental risks for AD.

Within this project we aim to identify contributors to AD risk and possible confounders of the plasma biomarkers, by measuring blood-based biomarkers in blood samples collected in the Netherlands Twin Register (NTR) Biobank study and combine these with the already very rich set of characteristics longitudinally obtained through the NTR (e.g. demographics, lifestyle, mental health, medication use, and comorbidities). We are looking for a PhD-student who is fully committed to this exciting and clinically relevant project.

Vragen over deze functie?
Tanja Hart Tanja Hart +31621603178 Recruitment adviseur
Wat ga je doen?

The main tasks and resposibilities as a PhD candidate are:

- Coordinating and performing blood-biomarker analyses at the Amsterdam UMC Neurochemistry lab

- Statistical analyses, including multivariate genetic analyses, of the blood-biomarkers and longitudinally obtained NTR data

- Writing scientific articles that lead to a PhD thesis

- Active participation in scientific meetings of both the Neurochemical lab, Alzheimer Center, and the department of Biological Psychology, in which you will also present your own work.

Wat neem je mee?

We are looking for a PhD candidate with the following characteristics:

  • Masters degree in (behavioral) genetics, biostatistics, or biomedical sciences
  • Affinity with and expertise in statistical analyses and programming in relevant packages (R, STATA, SPSS)
  • Experience with or strong interest in laboratory research
  • Excellent communicative and organising skills
  • Fluent in English (written and verbal)

You have affinity with both behavioral genetics and laboratory research. You are pro-active, with great communicative and  organising skills. You will form the link between the Neurochemistry laboratory and department of Biological Psychology - Netherlands Twin Register and will actively participate in the activities of these departments. You are able to develop yourself in a short time as a full-fledged discussion partner within the project groups

Wat bieden we jou?
  • A contract for one year (12 months) with the intention to extend for another 36 months.
  • Besides a good basic salary, you will also receive an 8.3% year-end bonus and 8% holiday allowance. Calculate your net salary here.
  • Free and unlimited access to our online learning environment GoodHabitz.
  • Pension accrual with ABP, of which we pay 70% of the premium.
  • Reimbursement of 75% of your public transport costs. Would you rather travel by bike? Then we have a good bicycle scheme.
  • An active personnel association and the Young Amsterdam UMC association, both of which organise fun (sports) activities and event
Waar ga je werken?

You will be working at both the  Neurochemistry Laboratory of the AUMC, location VUmc, and the department of Biological Psychology, Vrije Universiteit Amsterdam. The mission of the Amsterdam UMC Neurochemistry laboratory is to improve patient care for neurological disorders by developing biomarkers in body fluids. A primary area of ​​attention is the early diagnosis of dementia, for which there is close collaboration with the Alzheimer Center. 

The department of Biological Psychology longitudinally collects blood-based biomarkers, lifestyle, personality, social, and environmental characteristics in twins and their family members at multiple waves across the lifespan. With this extensive longitudinal data collection coupled with in-depth genotypic profiling, their goal is to indentify the degree to which genetic and environmental factors impact on health behaviors and health outcomes  and thereby to contribute to improvement of health care.

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The first round of interviews will take place around the end of May. Start of the project will be around August.

During the publication period, applications will be handled continuously. If the vacancy is filled, it will be closed prematurely.

For more information regarding the project and position you can contact, Anouk den Braber via a.denbraber@amsterdamumc.nl.

For more information about the application process please contact Tanja Hart, Recruitment adviser, via 06-21603178 or via tanja.hart@amsterdamumc.nl.

A reference check, screening and hiring test may be part of the procedure. Read here whether this also applies to you. If you join us, we ask for a VOG (Certificate of Good Conduct).

In case of equal suitability, internal candidates will be given priority over external candidates.

Acquisition in response to this vacancy is not appreciated.