Alzheimer’s Disease (AD) is the most common cause of dementia. Recent studies showed blood-based biomarkers to be promising for identifying core pathologies of AD, even in the predementia stage where individuals still show normal cognitive functioning. In order to develop treatment strategies for AD, we need to know which factors drive the first pathological signs. Twin and family studies can be powerfull in identifying genetic and environmental risks for AD.
Within this project we aim to identify contributors to AD risk and possible confounders of the plasma biomarkers, by measuring blood-based biomarkers in blood samples collected in the Netherlands Twin Register (NTR) Biobank study and combine these with the already very rich set of characteristics longitudinally obtained through the NTR (e.g. demographics, lifestyle, mental health, medication use, and comorbidities). We are looking for a PhD-student who is fully committed to this exciting and clinically relevant project.
The main tasks and resposibilities as a PhD candidate are:
- Coordinating and performing blood-biomarker analyses at the Amsterdam UMC Neurochemistry lab
- Statistical analyses, including multivariate genetic analyses, of the blood-biomarkers and longitudinally obtained NTR data
- Writing scientific articles that lead to a PhD thesis
- Active participation in scientific meetings of both the Neurochemical lab, Alzheimer Center, and the department of Biological Psychology, in which you will also present your own work.
We are looking for a PhD candidate with the following characteristics:
You have affinity with both behavioral genetics and laboratory research. You are pro-active, with great communicative and organising skills. You will form the link between the Neurochemistry laboratory and department of Biological Psychology - Netherlands Twin Register and will actively participate in the activities of these departments. You are able to develop yourself in a short time as a full-fledged discussion partner within the project groups
You will be working at both the Neurochemistry Laboratory of the AUMC, location VUmc, and the department of Biological Psychology, Vrije Universiteit Amsterdam. The mission of the Amsterdam UMC Neurochemistry laboratory is to improve patient care for neurological disorders by developing biomarkers in body fluids. A primary area of attention is the early diagnosis of dementia, for which there is close collaboration with the Alzheimer Center.
The department of Biological Psychology longitudinally collects blood-based biomarkers, lifestyle, personality, social, and environmental characteristics in twins and their family members at multiple waves across the lifespan. With this extensive longitudinal data collection coupled with in-depth genotypic profiling, their goal is to indentify the degree to which genetic and environmental factors impact on health behaviors and health outcomes and thereby to contribute to improvement of health care.
The first round of interviews will take place around the end of May. Start of the project will be around August.
During the publication period, applications will be handled continuously. If the vacancy is filled, it will be closed prematurely.
For more information regarding the project and position you can contact, Anouk den Braber via email@example.com.
For more information about the application process please contact Tanja Hart, Recruitment adviser, via 06-21603178 or via firstname.lastname@example.org.
In case of equal suitability, internal candidates will be given priority over external candidates.
Acquisition in response to this vacancy is not appreciated.