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PhD Development of therapy for osteogenesis imperfecta

Do you want to make a difference in finding a cure for osteogenesis imperfecta?
PhD Development of therapy for osteogenesis imperfecta
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Solliciteer direct
  • Aantal uur: 36 uur per week
  • Werklocatie: Locatie VUmc
  • Contractvorm: bepaalde tijd
  • Salaris: € 2.631 - € 3.336
  • Reageer tot en met: 7 augustus 2022
Solliciteer direct Reageer binnen 1 dag(en)
Wat ga je onderzoeken?

Doctoral position of molecular/cell biologist at the Centre for Connective Tissue Research of Dr. D. Micha, Human Genetics Department, Amsterdam UMC.

The PhD student will be involved in the development of pharmacological and gene therapy for the rare genetic bone fragility disorder Osteogenesis Imperfecta (OI), mainly caused by defects in collagen type I (10.1007/s00439-021-02302-2). The project will focus on the advancement of therapeutic approaches by their study in both in vitro and in vivo models of OI.

The project will be performed at the modernly equipped O|2 Lab Building and other facilities across Amsterdam UMC.

Vragen over deze functie?
Tanja Hart Tanja Hart +31621603178 Recruitment adviseur
Wat ga je doen?

You will work on a unique project which aims the development of a stem cell type in which genetic modifications can be applied to promote bone tissue regeneration. You will specifically use CRISPR technology in combination with numerous methods by which generation and validation of osteogenic cell types can be investigated. You will also characterize a new OI in vivo model, in which candidate compound testing will be performed. 

As a PhD candidate, you are committed to conduct independent and original scientific research, to report on this research in international publications and presentations, and to present the results of the research in a PhD dissertation, to be completed within 4 years.

Wat neem je mee?

We are looking for a highly ambitious, motivated and enthusiastic PhD candidate with a strong background in molecular & cell biology, genetics or biotechnology.

The successful applicant has:

  • Master in biomedical sciences (if not graduated yet, please indicate the expected graduation date)
  • research experience in molecular/cell biology (or closely related fields);
  • extensive experience in cell culture and molecular biology techniques (handling of iPSCs and CRISPR will be regarded as strong points)
  • excellent oral and written communication skills in English;
  • creative, open and resilient mind;
  • excellent interpersonal skills combined with an ability to work efficiently both independently and in a team;
  • experience with translational research working with in vivo models (article 9) will be considered advantageous.
Wat bieden we jou?
  • A contract for one year (12 months) with the intention to extend for another 36 months.
  • Besides a good basic salary, you will also receive an 8.3% year-end bonus and 8% holiday allowance. Calculate your net salary here.
  • Free and unlimited access to our online learning environment GoodHabitz.
  • Pension accrual with ABP, of which we pay 70% of the premium.
  • Reimbursement of 75% of your public transport costs. Would you rather travel by bike? Then we have a good bicycle scheme.
  • An active personnel association and the Young Amsterdam UMC association, both of which organise fun (sports) activities and event
Waar ga je werken?

The Center for Connective Tissue Research specialises for many years on the study of genetic bone disorders. Starting from the genetics, we perform basic, translational and clinically oriented research to address the diverse pathologies of bone conditions. 

Amsterdam UMC, Locatie VUmc - CBO; Centrum voor Bindweefsel Onderzoek; for Connective Tissue research

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During the publication period, applications will be handled continuously. If the vacancy is filled, it will be closed prematurely.

Start date is preferably as soon as possible.

Do you have questions? For questions on the content you can contact Dr. Dimitra Micha via d.micha@amsterdamumc.nl.

For more information on the procedure you can contact Tanja Hart, Recruitment Advisor, via t.hart@amsterdamumc.nl.

A reference check and screening can be part of the procedure. Read here what this entails. If you would join us, we will ask for a VOG (Verklaring Omtrent Gedrag). 

Internal candidates will receive preference to external candidates, if equally qualified.

Acquisition regarding this job opening is not appreciated.