Understanding how the immune system interacts with cancer is crucial for effective cancer immunotherapy. Clinical and epidemiological data suggests a protective effect of vitiligo against non-melanoma skin cancer. In this project, you will explore this relation on multiple levels, in the field of cancer biology and immunology. You will investigate how vitiligo-based immune responses target basal cell carcinoma and squamous carcinoma.
You will pioneer on this topic and shape the project, based on your immunological knowledge and innovative ideas. You will perform in vitro research using patient-derived immune and tumor cells, as well as in vivo experiments using relevant mouse models. To better understand therapy response and determine potential tumor antigens, you will acquire experience in advanced technologies, such as using Opal multiplex immunohistochemistry, Imaging Mass Cytometry (Hyperion) and RNAseq on tumor samples. In parallel, as part of an ongoing line of research in the lab, you will also investigate the synergy of monobenzone-imiquimod immunotherapy in vivo in a pre-clinical melanoma model. This is a new project that can lead to a new research line with consecutive funding potential.
This research project is funded by a 3 year grant in collaboration with an industrial partner in the US, which provides the opportunity for you to interact with pharmaceutical industry during the project. This project contains a challenging new hypothesis with high impact research potential, to achieve new insights in skin cancer immunology. In addition, the project also harbours an extension of our ongoing research line on the development of vitiligo-inducing immuntherapy for melanoma. Depending on the results, you will be involved in the acquisition of consecutive funding to prolong the research line. This project thereby provides a new challenge for you to grow as independent researcher as well as optimal embedding in the research team.
We are looking for a highly motivated and enthusiastic Postdoctoral Researcher (Postdoc) with a strong interest in immunology and oncology.
The Laboratory of Expermental Dermatology (LED) of the department of Dermatology is specialized in translational and immunological research on pigment cell disorders of the skin, including vitiligo and melanoma. You will work in the LED research team of approximately 10 colleagues, including research technicians, postdocs, PhD students and research staff members. The LED team closely collaborates with clinical staff members leading to fruitful interactions between lab and clinic. The LED is located at the department of Medical Biology, with state-of-the-art research facilities. The department of Dermatology of the Amsterdam UMC is the NFU acknowledged national center of expertise for pigment cell disorders, which creates an inspiring environment of clinical and scientific expertise for translational research. The department is part of the Cancer Center Amsterdam and the Amsterdam Institute for Infection and Immunity (AII) which both offer an excellent scientific and social environment in the field of cancer immunology.
We look forward to receiving your motivation letter and CV within a list of publications.
Do you have any questions? For more information, please contact Prof. Dr. R.M. Luiten, via firstname.lastname@example.org.
For more information about the application process please contact Tanja Hart, Recruitment adviser, via 06-21603178.
A reference check, screening and hiring test may be part of the procedure. Read hier whether this also applies to you. If you join us, we ask for a VOG (Certificate of Good Conduct).