The task of the PhD will be to reveal the role of bone morphogenetic protein 10 expression on right heart adaptation and pulmonary vascular remodeling in pulmonary arterial hypertension. The project entails ex vivo, in vitro and in vivo analyses to 1. determine expression of BMP10 during disease progression; 2. identify transcription factors regulating BMP10 expression and 3. to identify novel compounds to target BMP 10 expression.
We seek a highly motivated and hard working scientist who can work independently and is creative in seeking solutions when encountering problems.
We will offer a working environment in which the translation from basic science to clinic is priority. The research of the pulmonary hypertension team is focused on diagnosis, treatment and understanding the pathophysiology of pulmonary vascular remodeling and right heart failure. This is a joint project between the PH research group of the Amsterdam UMC and the cell and chemical biology group of the Leiden University Medical Center. Although the candidate will be primarily appointed at the Amsterdam UMC, the candidate will be working at both the Amsterdam UMC as well as Leiden University Medical Center.
For more information about this position, you can contact mw. Dr. Frances Handoko- de Man, via firstname.lastname@example.org or Dr. Gonzalo Sánchez-Duffhues, G.Sanchez_Duffhues@lumc.nl.
For more information about the application process please contact Tanja Hart, Recruitment adviser, via 06-21603178 or via email@example.com.
In case of equal suitability, internal candidates will be given priority over external candidates.
Acquisition in response to this vacancy is not appreciated.