A 4-year PhD position is available in the departments of Radiology and Nuclear Medicine and Hematology at Amsterdam University Medical Center, location AMC. Sickle Cell Disease (SCD) is a hereditary hemoglobinopathy that causes red blood cells to form a sickle shape in a deoxygenated state. Chronic hemolytic anaemia and vascular occlusion are symptoms of the disease. The prevalence of silent stroke in SCD is high, and there is no test to assess the risk of silent stroke in SCD. SCD pathophysiology in the brain can now be studied using advanced imaging technology such as magnetic resonance imaging (MRI). Over the last decade, the AMC group has established a strong research line in sickle cell disease imaging, employing both arterial spin labelling and 4D flow MRI to assess cerebrovascular impairment.